Spermidine Supplement Product Reviews and Facts
TABLE OF CONTENTS
What is Spermidine?
Pure vs Extracted / Dangers
Spermidne Benefits
Spermidine Foods
3 WAYS TO SPOT A FAKE
WHY IS GMP CERTIFICATION CRITICAL?
Spermidine Supplements – Product Reviews
THE ULTRAHEALTH STORE / BACKGROUND
The UltraHealth Store (UltraHealth LLC) stands at the forefront of scientific innovation as a biochemical enterprise, specializing in the creation and production of pharmaceutical-grade anti-aging compounds with a purity of over 99%. In collaboration with our FDA-approved cGMP partner and our umbrella corporation, GSK International, we have consistently delivered top-notch products rooted in science to researcher and consumers since 2015.
The supplement industry, although crowded, often grapples with inconsistent regulation. This leads to a proliferation of information that can be biased or purely promotional. In contrast, UltraHealth's foundation lies in the concrete evidence obtained from stringent clinical trials, drawing data from esteemed sources like the National Institute of Health, the Journal of Biological Chemistry, and ongoing studies from leading U.S. health institutions.
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What is Spermidine and 3HCL?
Recent scientific advancements in the landscape of health and wellness are literally a lifesaver who are constantly striving by leaps and bounds to be aware of humankind and their biological relationship with such natural components that have always been a part of life but not a prominent one. Spermidine is one such remarkable innovation about which little has been known till today. It is present naturally in many foods and health-friendly artificial forms, richly extracted from organic sources.
The discovery of spermidine is one of the most extraordinary incidents in the world of scientific explorations. The polyamines, spermidine, and spermine were first brought to light in 1678 by Antonie van Leeuwenhoek while examining a sample of human semen. Within a short time, its rich presence was also witnessed, specifically in human sperm.
Spermidine is a polyamine, a class of compounds that play diverse roles in cell growth and function. Over the years, research has uncovered its presence in various organisms, including bacteria, plants, and animals, and its role in a massive array of cellular processes.
In addition, the supplemental form of spermidine is also manufactured by a great many pharmaceutical and nutraceutical industries. It is a naturally occurring aliphatic polyamine – consisting of two or more amino groups in its chemical structure.
Spermidine is widely encountered in the ribosomes (cellular structures responsible for making proteins) and living tissues to carry out a diversified range of cellular processes. It has gained interest in recent years due to its potential anti-aging and autophagy-inducing properties. Autophagy is the body's way of cleaning out damaged cells in order to regenerate newer, healthier cells.
The "3HCl" refers to a trihydrochloride salt form of spermidine. The addition of hydrochloride (HCl) is common in pharmaceuticals and laboratory compounds to improve solubility or stability. In this case, "3HCl" would suggest that there are three molecules of hydrochloride for every molecule of spermidine.
Pure vs Extracted / Dangers
The majority of extracted spermidine comes from China and is used by most of the supplement companies in the U.S. Unfortunately much of the following is true for most of the resveratrol supplement products sold today also.
UltraHealth synthesizes 99+% pure spermidine in our labs and does not purchase wheat extracted spermidine from China.
The National Library of Medicine has stated that there is Fusarium Toxins in Chinese Wheat since the 1980s.
Also, the way it is extracted causes concerns for biochemists and the poor regulations in many areas of Asia.
The safety of Chinese wheat, as with wheat from any other country, depends on various factors such as agricultural practices, environmental conditions, storage conditions, and processing methods. Here are some considerations when evaluating the safety of Chinese wheat:
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Pesticides and Herbicides: The use of certain chemicals in agriculture varies by country. It's essential to check whether the wheat has been grown using safe levels of pesticides and herbicides, as per international standards.
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Heavy Metals: In some regions, soil contamination with heavy metals, such as cadmium or lead, is a concern. Crops grown in such soils might take up these metals, potentially posing a health risk.
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Mycotoxins: If wheat is not stored correctly, it can become contaminated with fungi that produce mycotoxins, which can be harmful to health.
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Genetically Modified (GM) Crops: While GM crops are subject to rigorous safety testing before they are approved for commercial use, some people prefer to avoid them. It's worth checking if the wheat is GM and if it has been approved for consumption.
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Regulation and Testing: China's food safety regulations have been tightened in recent years, especially after some high-profile food safety incidents. The country has been working on improving food quality and safety standards.
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Trade and Import Standards: If you're purchasing Chinese wheat or products made from it outside of China, it's also worth considering the import and safety standards of the country you're in.
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Organic vs. Conventional: Organic wheat from China, like elsewhere, would be grown without synthetic pesticides, herbicides, and fertilizers, and might be preferred by those seeking to reduce exposure to these chemicals.
Given that Chinese firms involved in the extraction of spermidine from different regional wheat sources often don't share details about their manufacturing processes, storage, or pesticide usage, it's prudent to exercise caution. There are toxins that might not be accounted for, and the Certificates of Analysis (COAs) provided by some Chinese enterprises can be, at times, inaccurate or misleading.
Spermidine Benefits
Similar to any other naturally occurring nutritious component in human bodies, the levels of spermidine also start decreasing with age, thereby necessitating the need to incorporate your diet and wellness regime with spermidine supplementation to prevent or delay age-related diseases. However, it is recommended to seek professional guidance for balanced meals, medications, or supplements instead of mindlessly following the trends of health, mainly circulated by social media influencers.
Spermidine is a polyamine compound that is found in small amounts in various foods and is also synthesized within the body from its precursor, 'putrescine.'
Putrescine also serves as a precursor to 'spermine' – another polyamine that plays a crucial role in regulating cellular functions. Over the past several years, spermidine has piqued the interest of researchers for its potential health benefits, some of which are described as follows:
One of the most well-studied benefits of spermidine is its role in inducing autophagy, a cellular process in which cells break down and recycle damaged components. Autophagy has been linked to various health benefits, including protection against neurodegenerative diseases, improved longevity, and reduced tissue inflammation.
Along with spermidine, its precursor putrescine also assists in the stimulation of breaking down cellular debris or waste to recycle new cellular components. This process is of substantial importance and serves as a quality control mechanism for mitochondria – the powerhouses of the cells. Furthermore, degenerated mitochondria are also subject to spermidine-dependent autophagy, contributing to enhanced energy synthesis in your body.
Some studies suggest that spermidine may be beneficial for cardiovascular health. Dietary spermidine has been shown to reduce arterial stiffness, decrease blood pressure, and lower the risk of cardiovascular disease in some animal models and observational studies in humans.
There's evidence from animal studies that spermidine supplementation can extend lifespan. The proposed mechanism is often related to its role in enhancing autophagy, which might counteract age-related cellular decline. Integrated efforts of spermidine and other polyamines enhance the activity of growth factors during the process of cell division. Therefore, it is essential for healthy tissue growth.
Given its role in promoting autophagy, spermidine might offer neuroprotective effects. This could make it beneficial in conditions such as Alzheimer's disease or other neurodegenerative disorders. However, more research is needed to confirm this in humans.
In some experimental models, spermidine has been shown to suppress tumor growth. Its potential anti-cancer effects might be related to its role in inducing autophagy and promoting cell differentiation.
Preliminary studies in mice have suggested that spermidine might promote hair shaft elongation and prolong the active growth phase of hair. This hints at a potential role in managing hair loss, though further studies are needed to confirm these effects in humans.
Spermidine can modulate immune responses, and its role in autophagy can help in the efficient removal of pathogens and reduce chronic inflammation.
It is important to note that while the potential benefits of spermidine are promising, many of the studies have been conducted in animals or in vitro.
Autophagy is a highly regulated cellular process where the cell degrades its own components through the lysosomal machinery. The term "autophagy" is derived from the Greek words "auto" (self) and "phagein" (to eat), effectively meaning "self-eating." This process serves as both a quality control mechanism, ridding cells of damaged or dysfunctional components, and as a resource-recycling mechanism during periods of nutrient stress.
Here's a brief overview of autophagy stimulation:
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Initiation: In response to cellular stress signals—like nutrient deprivation, hypoxia, or damaged organelles—the process of autophagy begins. The initial structure that forms is called the phagophore, which is a flat membranous sac.
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Nucleation: The phagophore expands and starts to envelop the damaged cell components or unwanted materials. This process is regulated by a complex of proteins, and one of the primary ones is initiated by the ULK1 (Unc-51 Like Autophagy Activating Kinase 1) complex.
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Expansion and Completion: The expanding phagophore eventually forms a double-membrane structure called an autophagosome. This structure surrounds and traps the materials targeted for degradation.
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Fusion with Lysosome: Once the unwanted materials are encapsulated within the autophagosome, it fuses with a lysosome to form an autolysosome. Lysosomes contain digestive enzymes that break down and degrade the trapped materials.
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Degradation: Inside the autolysosome, the cellular waste is degraded into its basic components like amino acids, fatty acids, and sugars. These components can be recycled by the cell to generate energy or build new cellular components.
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Release of Recycled Components: The degraded and recycled materials are released back into the cytoplasm for reuse by the cell.
Stimulation of Autophagy: Several factors can stimulate autophagy, including:
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Starvation or nutrient deprivation: This is one of the most potent inducers of autophagy. When cells lack essential nutrients, they turn to autophagy to degrade and recycle components, providing essential building blocks and energy.
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Mitochondrial damage: Dysfunctional mitochondria can be harmful to cells. Autophagy helps remove these damaged mitochondria in a specific process called mitophagy.
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Infections: Some pathogens can be targeted and eliminated through autophagy.
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Exercise: Physical activity has been shown to induce autophagy in certain tissues.
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Certain drugs and compounds: For example, rapamycin, a drug originally developed as an immunosuppressant, is a well-known autophagy inducer. Spermidine also promotes autophagy.
Stimulating autophagy has been linked to numerous health benefits, including enhanced longevity, improved metabolism, reduced inflammation, and protection against certain diseases like neurodegenerative disorders. However, it's worth noting that excessive or dysregulated autophagy can also be detrimental, underscoring the need for a balanced process.
Spermidine Foods
Spermidine is found in various foods, albeit in varying concentrations. Incorporating these foods into your diet can help increase spermidine intake:
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Wheat germ: One of the richest sources of spermidine. Fresh, unprocessed wheat germ tends to have higher levels than the toasted variety.
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Matured cheeses: Especially aged varieties like blue cheese, cheddar, and brie. Fermented cheeses are particularly rich in spermidine.
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Mushrooms: Certain types of mushrooms, such as shiitake, are a good source.
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Legumes: Lentils, chickpeas, and soybeans contain moderate amounts of spermidine.
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Whole grains: Options like barley and whole wheat.
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Nuts and seeds: Especially almonds and peanuts.
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Vegetables: Particularly green peas, cauliflower, broccoli, and potatoes.
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Fruits: Apples, pears, and mangos are among the fruits containing spermidine.
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Meats: Chicken liver is known to contain spermidine, but in general, plant-based sources tend to be richer.
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Fermented foods: Fermented soy products like natto and tempeh, as well as fermented vegetables like sauerkraut, can be good sources of spermidine.
It's worth noting that while dietary spermidine can provide certain health benefits, it's also essential to maintain a balanced diet and avoid excessive consumption of any single food. As research on spermidine's health effects is still ongoing, it's advisable to approach the topic with a balanced perspective and consider all aspects of a healthy lifestyle.
To see a complete list of foods containing spermidine (table 1) go to: LINK
3 WAYS TO SPOT A FAKE
It's regrettable, but the surest way to verify the authenticity of a dietary supplement is by getting it tested yourself, even though it can be costly.
Major online retailers like Amazon, Walmart, and iHerb can't always be counted on to filter out subpar products. Many supplement companies resort to using counterfeit test reports, reviews, and GMP certifications to market their questionable items. Numerous supplement review websites that appear in Google searches do not conduct thorough investigations into the products they endorse. These sites primarily profit from referral commissions, and their genuine concern for consumers receiving low-quality or potentially harmful supplements is questionable, despite their claims otherwise.
There are also free methods you can use to independently research dietary supplement companies.
We will explain what the following free tools will help you discover from just a simple review of a products label.
- UPC lookup link - GS1
- FDA supplement label regulations link - FDA Label
- GMP Company lookup link - FDA Database
1. UPC code lookup - If your supplement bottle has a UPC code just go to GS1 and scroll down and select GTIN (which is the official name for a UPC code) and type the full number into the search box. Once you click search it will only take seconds for this government database to retrieve the company's information. It may say the UPC code is not valid which means it is not a real UPC code.
Also, if the company name comes up and does not match the company you are looking at it may have been copied and put on the bottle without permission. You should avoid this company.
One can also look up the company name if you cannot find a UPC code or the company does not show it on their site. If the company does not have any UPC codes associated with their company name then they do not use UPC codes.
2. FDA supplement label regulations - Look at the right side of your supplement bottle were the 'Supplement Facts' are located. This label should have the correct name of the active ingredient, dose, dosage amount, and the complete address of the company selling or having 'manufactured for' in this area. To see the complete set of regulations for dietary supplement labeling just click this link: FDA Label.
If a company's label isn't in line with FDA regulations, it suggests they aren't adhering to certified GMP standards, as a genuine GMP would prevent bottles from being mislabeled or lacking essential information. Again, you probably should not use this company's products.
The example above shows spermidine correctly. The certified GMP would receive the bulk compound with the proper COA (certificate of analysis) which would state which type of spermidine was being provided. If just spermidine was listed it would be wrong if the GMP received 3HCL and the GMP would not complete manufacturing.
3. GMP Company lookup link - Almost no companies post their GMP certificate, which has the name of the FDA certified GMP company. If you have the GMP name you can just type it into the database search at this site: FDA Database. This will show you when the company was first started, how many times they have been inspected, and if they have any violations.
If your supplement company does not post this information call or email them and request it. If they do not provide this or say it is confidential be very cautious. Any legitimate company would be happy and proud to provide this to their customers.
WHY IS GMP CERTIFICATION CRITICAL?
GMP stands for "Good Manufacturing Practice." A certified GMP refers to a system for ensuring that products are consistently produced and controlled according to quality standards. When a facility is "certified GMP," it means the facility has been inspected and found to adhere to the GMP standards set by regulatory authorities.
The Food and Drug Administration (FDA) enforces GMP regulations for food, drug, and medical device manufacturers. If a company claims their products are produced in a "GMP certified" or "GMP compliant" facility, it means that their manufacturing processes have been audited and meet the stringent standards set by the respective regulatory authority.
GMP certification really does matter?
- Incoming testing of ingredients and final post manufacturing testing - safety inspections
- GMP will not complete the manufacturing unless the labeling is accurate and complete
- Companies using a certified GMP cannot get away with providing false label claims and unsafe products
how to ask a supplement company for their GMP? Just contact them.
Dear company X,
"I would like to buy (or continue buying) your product, but I would like to have the name of your GMP so that I can contact them."
By simply examining the FDA label information, it becomes evident that the majority of the companies that failed were not legitimate. When we reviewed the labels of these unsuccessful companies, we found that none of them met FDA guidelines.
Spermidine Supplements – Product Reviews
We've assessed the companies listed below based on their current spermidine offerings. Our analysis prioritizes information verifiable through government websites, ensuring the product labels adhere to regulations and legal standards. We also examine bioavailability, considering factors like liposomal formulation and the presence of additives versus pure active ingredients, as well as whether the product is extracted or synthesized. When all other factors are consistent, we rank the products based on the cost per gram of spermidine.
Some companies claim to be liposomal, they are not. We have technical information in our 'The Lipo Lie' blog: LINK. It is a must read.
The ranking scale is from 0 to 6. Scores of 2 and above are considered trustworthy. Companies with scores below 2 are ones we recommend approaching with caution or avoiding altogether.
UltraHealth spermidine 3HCL - Score 5 out of 6
The only company posting their real GMP certificate, real Liposomal capsules, & only one inert additive.
PEAK PERFORMANCE SPERMIDINE - 2
DOUBLEWOOD SPERMIDINE - 2
VERSO SPERMIDINE - 2
The above companies are considered reliable.
DO NOT AGE SPERMIDINE - 0
RENUE BY SCIENCE SPERMIDINE - 0
OMRE SPERMIDINE - 0
PUROVITALIS SPERMIDINE - 0
SPERMIDINE LIFE - 0
PRIMEADINE - 0
The above companies are suspicious and should be avoided.
NOTE:
Here is how to calculate cost per gram of the active ingredient:
- serving per bottle x mg per serving - X (mg per bottle)
divide X by 1000 = Y (grams per bottle)
divide the price of one bottle by Y = $/gram
BUY NOW!
UltraHealth Spermidine - Score 5
| Price per gram |
$60.00 / gram* |
| Dosage per Capsule | 10 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) |
yes |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | yes |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | 860009953901 |
|
GMP Certification number |
11625918556 |
| * includes our VC10 discount for 10% off |
PEAK PERFORMANCE - Score 2
| Price per gram |
$60.57 / gram |
| Dosage per Capsule | 10 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | no |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
no |
DOUBLEWOOD - Score 2
| Price per gram |
$66.58 / gram |
| Dosage per Capsule | 5 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | ? |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
no |
VERSO - Score 2
| Price per gram |
$333 / gram |
| Dosage per Capsule | 6 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | ? |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
no |
DO NOT AGE - 0
| Price per gram |
$102.08 / gram |
| Dosage per Capsule | 8 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | ? |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no |
|
GMP Certification number |
no |
RENUE BY SCIENCE NMN - Score 0
| Price per gram |
$3.77 / gram |
| Dosage per Capsule | 250 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | ? |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no |
|
GMP Certification number |
no |
OMRE - Score 0
| Price per gram |
$149.09 / gram |
| Dosage per Capsule | 5 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | no |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no |
|
GMP Certification number |
no |
PUROVITALIS - Score 0
| Price per gram |
$395.40 / gram |
| Dosage per Capsule | 5 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | ? |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no |
|
GMP Certification number |
no |
SPERMIDINE LIFE - Score 0
| Price per gram |
$819.44 / gram |
| Dosage per Capsule | 1.2 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | no |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no |
|
GMP Certification number |
no |
PRIMEADINE - Score 0
| Price per gram |
$3,000.00 / gram |
| Dosage per Capsule | 0.34 mg |
| absorption / safety criteria | |
| Pure synthesized (not extracted) | no |
| Pure, no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no |
|
GMP Certification number |
no |
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NMN Supplements – Product Reviews
We have not included some companies because they are lesser know, in other overseas countries or to awful to list.
Please us our contact page to ask any questions or request a company to be reviewed.